Biochemistry (BIOC)

BIOC 545. Biochemistry I3 Units

Description: Chemistry of amino acids, peptides, proteins, nucleotides and nucleic acids; methods of analysis and laboratory synthesis; nucleotides; RNA, DNA and protein biosynthesis.

Note: Credit may not be earned in both BIOC 545 and BIOC 645.
Note: Credit may not be applied toward an advanced degree in Chemistry.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 547. Biochemistry II3 Units

Prerequisite(s): BIOC 545.

Description: Cellular metabolism of carbohydrates, lipids, amino acids and biomembrane phenomena, enzyme properties, kinetics, and control mechanisms; ligand binding.

Note: Credit may not be earned in both BIOC 547 and BIOC 647.
Note: Credit may not be applied toward an advanced degree in Chemistry.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 603. Special Topics in Biochemistry1-4 Units

Prerequisite(s): BIOC 645 and BIOC 647 (or concurrently), or consent of instructor.

Description: Arranged to fit individual needs on topics of current interest or to receive some advanced training or conduct research project.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 606. Biochemistry Seminar1 Unit

Description: Both Fall and Spring semesters.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 611. Advanced Techniques in Biochemistry and Molecular Biology4 Units

Prerequisite(s): BIOC 645 or equivalent; restricted to Biochemistry & Molecular Genetics graduate students.

Description: An introduction to modern biochemical and molecular biology methods in lecture and laboratory format. Methodologies covered include: DNA cloning and sequencing, RNA isolation and quantitative PCR, bioinformatics analysis, transfection and RNA knockdown approaches, immunoprecipitations and protein detection, and enzyme characterization.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 613. Biochemistry Laboratory2-4 Units

Grading Basis: Pass/Fail

Description: The course will consist of participation in the research programs of two laboratories in the department. A half-semester will be devoted to each laboratory. Pass/Fail grading.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 619. Research1-15 Units

Grading Basis: Pass/Fail

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 620. Scientific Method and Grant Writing2 Units

Term Typically Offered: Spring Only

Prerequisite(s): Restricted to students in the Biochemistry and Molecular Genetics graduate programs; permission of course director.

Description: This objective of this course is to introduce students to the fundamentals of grantsmanship. The topics incorporate all aspects for grant application process as well as overview of the scientific method, generation of hypotheses, and research design. Student-directed learning is a major component for this course with the summative event being completion of a grant proposal. A reiterative writing process for proposal development will be ongoing throughout the course.

Note: May be repeated once for up to 4 credits.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 630. Responsible Conduct of Research: Survival Skills and Research Ethics1-4 Units

Grading Basis: Pass/Fail

Description: The topics covered include 11 areas of Research Compliance training mandated by the NIH for training grants and focuses on contemporary research ethics in biomedical sciences.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 640. Principles of Biochemistry5 Units

Prerequisite(s): Consent of instructor.

Description: Covers general aspects of biochemistry with special emphasis given to areas applicable to dentistry. Topics include protein structure and function; chemistry and metabolism of carbohydrates, lipids, amino acids, and nucleotides; molecular genetics; nutritional biochemistry; calcification; and molecular endocrinology. Clinical conferences keyed to current lecture topics are presented by clinical faculty. Spring.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 645. Advanced Biochemistry I4 Units

Description: Chemistry of amino acids, peptides, proteins, nucleotides and nucleic acids; methods of analysis and laboratory synthesis; nucleotides; RNA, DNA and protein biosynthesis.

Note: Credit may not be earned in both BIOC 545 and BIOC 645.
Note: Credit may not be applied toward an advanced degree in Chemistry.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 647. Advanced Biochemistry II4 Units

Prerequisite(s): BIOC 645.

Description: Cellular metabolism of carbohydrates, lipids, amino acids and nucleotides; enzyme properties, kinetics, and control mechanisms, ligand binding; biomembrane phenomena.

Note: Credit may not be earned in both BIOC 547 and BIOC 647.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 661. Molecular Mechanisms of Toxicology3 Units

Prerequisite(s): BIOC 668 or approval by course directors or program directors.

Description: Molecular interactions of drugs and toxicants on cellular processes; including foreign compound metabolism, signal tranduction, cell cycle, DNA repair/DNA replication are covered and put in context topics in molecular epedimiology.

Note: Crosslisted with PHTX 661.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 662. Biomedical Research Data Analysis Methods1 Unit

Grading Basis: Pass/Fail

Term Typically Offered: Summer Only

Prerequisite(s): Currently enrolled graduate students in good standing.

Description: A lecture and discussion course designed for graduate students desiring to learn the basic statistical methods and data presentation approaches that are used in biomedical research.

Note: This course requires permission from the instructor.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 667. Cell Biology3 Units

Prerequisite(s): One quarter of graduate level biochemistry or consent of instructor.

Description: An advanced treatment of contemporary cell biology including membrane structure and function, cytoskeleton, signal transduction, regulation of cell cycle, apoptosis, and molecular mechanisms of cellular differentiation. Graded. Spring semester only

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 668. Molecular Biology and Genetics4 Units

Prerequisite(s): BIOC 645 and BIOC 647 or consent of course director.

Description: This course examines the fundamental principles of genetics and molecularbiology as they apply to molecular and cellular processes. Topics include: Mendelian, population, and quantitative genetics; epigenetics; bioinformatics; mechanisms controlling transcriptional and post-transcriptional regulation of gene expression: RNA and miRNA biology; and protein synthesis and regulation. An emphasis will be on reading and critiquing current literature.

Note: Crosslisted with BIOL 668.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 675. Cancer Biology4 Units

Prerequisite(s): BIOC 545 or BIOC 645 or equivalents.

Description: A comprehensive course on cancer biology with emphasis on molecular mechanisms and research. Topics will include: the public health impact of cancer, molecular mechanisms of carcinogenesis and metastasis, host-tumor interactions, current and future molecular therapies and prevention, apoptosis, tumor immunology, cancer genetics and genomics, prevention, metabolism in cancer cells, signal transduction, cell cycle, and oncogenes and tumor suppressor genes. There will also be clinical-based lectures.

For class offerings for a specific term, refer to the Schedule of Classes

BIOC 680. Biomolecular Interactions2 Units

Prerequisite(s): BIOC 645 and BIOC 647 or equivalents.

Description: This course examines techniques used to characterize biomolecules and their interactions including surface plasmon resonance, equilibrium dialysis, microcalorimetry, analytical ultracentrifugation, dynamic light scattering and absorption fluorescence and circular dichroism spectroscopies.

For class offerings for a specific term, refer to the Schedule of Classes